Hydrazinecarboxaldehyde, 1-methyl- → HCID 58336807, compound

HRID 2358982Notes

Reaction equation

HRID 2358982 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[CH:11]=[C:10]([C:12]3[N:17]=[C:16]([C:18](=S)[NH2:19])[CH:15]=[CH:14][CH:13]=3)[CH:9]=[N:8]2)[CH:2]=1.[CH3:21][N:22]([CH:24]=O)[NH2:23]>>[CH3:24][N:22]1[CH:21]=[N:19][C:18]([C:16]2[CH:15]=[CH:14][CH:13]=[C:12]([C:10]3[CH:9]=[N:8][N:7]([C:3]4[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=4)[CH:11]=3)[N:17]=2)=[N:23]1

Participants

3

Reactant 2

HCID 12962Hydrazinecarboxaldehyde, 1-methyl-HCID 58336759HCID 58336759, compound

Product 1

HCID 58336807HCID 58336807, compound

Procedure

0.57 g (2 mmol) of 6-(1-pyridin-3-yl-1H-pyrazol-4-yl)pyridine-2-carbothioamide and 2.5 ml (27 mmol) of 1-methyl-1-formylhydrazine were stirred at 145° C. for 6 h. After cooling, the mixture was purified by chromatography on silica gel (cyclohexane/acetone).

Workup

  1. temperatureAfter cooling
  2. customthe mixture was purified by chromatography on silica gel (cyclohexane/acetone)

Sources & evidence

ORD record
ord-ae450d1907524a95ab92931adba55bde
Source dataset
uspto-grants-2014_04
Patent number
US08685964B2

Reaction notes

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