4-Nitroindazole → NoName_3327

HRID 2358993Notes

Reaction equation

HRID 2358993 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]=[N:7][NH:8]2)([O-])=O.[H][H]>[Pd].C(O)C>[NH:8]1[C:9]2[C:5](=[C:4]([NH2:1])[CH:12]=[CH:11][CH:10]=2)[CH:6]=[N:7]1

Participants

5

Reactant 2

HCID 180574-NitroindazoleHCID 178418361HCID 178418361, compound

Product 1

HCID 413085NoName_3327Yield 101.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4-nitro-1H-indazole (760 mg, 4.68 mmol), palladium on charcoal (10%, cat.) and ethanol (30 mL) was stirred under a balloon of hydrogen for 4 h. The reaction mixture was then filtered through celite, and the solvent removed in vacuo to yield 1H-indazol-4-ylamine (68) (631 mg, 100%).

Workup

  1. filtrationThe reaction mixture was then filtered through celite
  2. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-fb19f0e786bb4f8d880708533c3ab717
Source dataset
uspto-grants-2014_04
Patent number
US08685968B2

Reaction notes

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