Triethylamine → HCID 178478259, compound

Participants

Reaction Steps

To a solution of 3-(dimethylamino)-1-(3-chloro-2-thienyl)-2-(pyrimidin-4-yl)prop-2-en-1-one (1 eq, 20 mmol) in ethanol (60 mL) was added hydrazine hydrate (1.5 eq, 30 mmol) and triethylamine (1.5 eq, 30 mmol). The reaction mixture was stirred at reflux for 2 h. The mixture was evaporated under reduced pressure. The obtained residue was dissolved in dichloromethane (100 mL) and methanol (10 mL), washed with brine (3×50 mL), dried over Na2SO4 and concentrated. The crude product was suspended in ethylacetate, filtered and dried to afford 2.9 g of 4-(3-(3-chloro-2-thienyl)-1H-pyrazol-4-yl)pyridine (55% yield).

Provenance & Evidence