2-Acetylthiophene → 3-(Dimethylamino)-1-(2-thienyl)-2-propen-1-one

Participants

Reaction Steps

A mixture of 2-acetylthiophene (198 mmol) and N,N-dimethylformamide dimethyl acetal (297 mmol) was refluxed overnight and then allowed to cool to room temperature. The reaction mixture was concentrated under reduced pressure and dried in vacuo to afford 36 g (100% yield) of 3-(dimethylamino)-1-(2-thienyl)prop-2-en-1-one which was used in the next step without further purification.

Provenance & Evidence