反应详情

To a solution of 4-bromo-2-aminopyridine (580 mmol) in 1.5 L dichloromethane was added pyridine (1.16 mol). The mixture was stirred for 20 min. Propionyl chloride (669 mmol) was added dropwise. The reaction mixture was stirred at room temperature for 5 h. Water was added and the reaction mixture was extracted with dichloromethane. The combined organic layer was washed with brine, dried and concentrated. The residue was recrystallized from hexane/ethyl acetate (6:1) to afford 112 g of N-(4-bromopyridin-2-yl)propanamide (85% yield).

1. stirringThe reaction mixture was stirred at room temperature for 5 h
2. extractionthe reaction mixture was extracted with dichloromethane
3. washThe combined organic layer was washed with brine
4. customdried
5. concentrationconcentrated
6. customThe residue was recrystallized from hexane/ethyl acetate (6:1)