1-Bromo-3,5-dimethoxybenzene → 2-(3,5-Dimethoxyphenyl)furan

HRID 2359202Notes

Reaction equation

HRID 2359202 reaction equation
Br[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([O:10][CH3:11])[CH:3]=1.[O:12]1[CH:16]=[CH:15][CH:14]=[C:13]1B(O)O>>[CH3:11][O:10][C:4]1[CH:3]=[C:2]([C:13]2[O:12][CH:16]=[CH:15][CH:14]=2)[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=1

Participants

3

Reactant 2

HCID 6391871-Bromo-3,5-dimethoxybenzeneHCID 2734357Furan-2-boronic acid

Product 1

HCID 584320952-(3,5-Dimethoxyphenyl)furan

Procedure

1-Bromo-3,5-dimethoxybenzene was coupled with 2-furylboronic acid following the procedure for Example 21. 2-(3,5-Dimethoxyphenyl)furan was isolated as a colorless liquid (0.746 g, 79% yield).

Sources & evidence

ORD record
ord-6a0650edecfc498fa0a25d36e9ff588d
Source dataset
uspto-grants-2014_04
Patent number
US08685975B2

Reaction notes

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