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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2359205Generated: October 31, 2026

Furan-2-boronic acid → 2-(4-(Difluoromethoxy)-3,5-dimethoxyphenyl)furan

https://huagongshe.com/reaction/2359205

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFuran-2-boronic acidHCID 2734357—
Reactant5-Bromo-2-(difluoromethoxy)-1,3-dimethoxybenzeneHCID 58432071—
Product2-(4-(Difluoromethoxy)-3,5-dimethoxyphenyl)furanHCID 58432053—

Reaction Steps

5-Bromo-2-(difluoromethoxy)-1,3-dimethoxybenzene was coupled with 2-furylboronic acid following the procedure for the synthesis of Example 21. Purification by chromatography (0-30% EtOAc-hexanes) provided 2-(4-(difluoromethoxy)-3,5-dimethoxyphenyl)furan as a white crystalline material (0.555 g, 67% yield).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08685975B2
Source datasetuspto-grants-2014_04
ORD IDord-8186097c275f4fb2888d421c3372a19f
Source noteuspto-grants-2014_04