HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,2-dimethoxy-N-methyl-2-(4-morpholinophenyl)acetamide → 1-(5-(4-(Difluoromethoxy)-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(4-morpholinophenyl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,2-dimethoxy-N-methyl-2-(4-morpholinophenyl)acetamide | HCID 58431993 | — |
| Reactant | 2-(4-(Difluoromethoxy)-3,5-dimethoxyphenyl)furan | HCID 58432053 | — |
| Product | 1-(5-(4-(Difluoromethoxy)-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(4-morpholinophenyl)-ethanone | HCID 58432000 | 6% |
Reaction Steps
2-(4-(Difluoromethoxy)-3,5-dimethoxyphenyl)furan was coupled with N,2-dimethoxy-N-methyl-2-(4-morpholinophenyl)acetamide following the procedure used for the synthesis of Example 12. Purification by chromatography (EtOAc-hexanes) provided 1-(5-(4-(difluoromethoxy)-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(4-morpholinophenyl)-ethanone as a brown oil (0.021 g, 6% yield). MS: m/z 504.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08685975B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-9b5fa70f494d4438bb7e8339ab890121 |
| Source note | uspto-grants-2014_04 |