反应详情

To a solution of 2-[p-(3-chloro-2-hydroxypropoxy)phenyl-4-trifluoromethylimidazole (1.92 g.) in methanol (100 ml.) is added crushed potassium hydroxide (1.5 g). The mixture is stirred 3 hours at room temperature, neutralized with acetic acid and concentrated under reduced pressure (20 mm. Hg. over steam. The residue is triturated with water (25 ml.), filtered and recrystallized by dissolving in benzene and adding hexane until turbid. A yield of 1.2 g. of 2-[4-(2,3-epoxypropoxy)phenyl]-4-trifluoromethylimidazole is obtained, m.p. 152°-153.5° C.

1. concentrationconcentrated under reduced pressure (20 mm. Hg
2. customThe residue is triturated with water (25 ml.)
3. filtrationfiltered
4. customrecrystallized
5. dissolutionby dissolving in benzene
6. additionadding hexane until turbid