Potassium Carbonate → HCID 56592632, compound

Participants

Reaction Conditions

Reaction Steps

To 2-fluorobenzonitrile (12.1 mg, 0.100 mmol) was added potassium carbonate (27.6 mg, 0.200 mmol) and a solution of 2,5-difluoro-4-hydroxy-N-(methylsulfonyl)benzamide (Preparation 34, 32.7 mg 0.130 mmol) in dimethyl sulfoxide (1.0 mL). The reaction mixture was shaken at 120° C. for 5 hours. The reaction mixture was purified on an HPLC column (DIKMA Diamonsil(2) C18 200*20 mm*5 um, acetonitrile-water (0.225% formic acid) gradient) to afford the title compound (3.50 mg, 9.93 μmol).

Provenance & Evidence