Potassium Carbonate → 4-Methylphenyl 5-chloro-4-[3-chloro-4-(trifluoromethyl)phenoxy]-2-fluorobenzoate

HRID 2359287Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2359287
[Cl:1][C:2]1[CH:3]=[C:4]([OH:12])[CH:5]=[CH:6][C:7]=1[C:8]([F:11])([F:10])[F:9].C(=O)([O-])[O-].[K+].[K+].CC1C=CC([C:26]2[C:27]([F:37])=[C:28]([CH:32]=[C:33]([Cl:36])[C:34]=2F)[C:29]([O-:31])=[O:30])=CC=1>CS(C)=O>[Cl:36][C:33]1[C:34]([O:12][C:4]2[CH:5]=[CH:6][C:7]([C:8]([F:10])([F:11])[F:9])=[C:2]([Cl:1])[CH:3]=2)=[CH:26][C:27]([F:37])=[C:28]([CH:32]=1)[C:29]([O:31][C:4]1[CH:5]=[CH:6][C:7]([CH3:8])=[CH:2][CH:3]=1)=[O:30]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 136091473-Chloro-4-(trifluoromethyl)phenolHCID 866608804-Methylphenyl-5-chloro-2,4-difluorobenzoate

Produkt 1

HCID 580463374-Methylphenyl 5-chloro-4-[3-chloro-4-(trifluoromethyl)phenoxy]-2-fluorobenzoateAusbeute 92,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

To a solution of 3-chloro-4-(trifluoromethyl)phenol (Preparation 16, 100 mg, 0.470 mmol) in DMSO (1 mL) was added potassium carbonate (0.84 mg, 0.611 mmol) and the mixture stirred for 5 minutes. 4-methylphenyl-5-chloro-2,4-difluorobenzoate (Preparation 10, 0.133 mg, 0.470 mmol) was then added and the reaction stirred under nitrogen for 3 hours. The reaction was quenched by the addition of water (2 mL) and ethyl acetate (3 ml). The organic layer was separated, dried over magnesium sulfate and concentrated in vacuo to afford a white solid that was purified using silica gel column chromatography eluting with ethyl acetate:heptane 3:97 to furnish the title compound (100 mg, 47%).

Aufarbeitung

  1. stirringthe reaction stirred under nitrogen for 3 hours
  2. customThe reaction was quenched by the addition of water (2 mL) and ethyl acetate (3 ml)
  3. customThe organic layer was separated
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated in vacuo
  6. customto afford a white solid
  7. customthat was purified
  8. washeluting with ethyl acetate:heptane 3:97

Quellen und Nachweise

ORD-Eintrag
ord-386b27ea5ec545df9c1bc582068ffebb
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08685977B2

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