3,4-Dichlorophenol → HCID 58046350, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3,4-dichlorophenol (539 mg, 3.31 mmol), 4-fluoro-3-methoxybenzonitrile (500 mg, 3.31 mmol) and cesium carbonate (2.16 g, 6.62 mmol) in DMSO (5 mL) was heated to 120° C. for 18 hours. The reaction was cooled before the addition of 1N NaOH. The reaction was extracted with ethyl acetate and the organic layer separated and concentrated in vacuo. The residue was purified using silica gel column chromatography eluting with 0-20% EtOAc in heptane to furnish the title compound as a white solid, 142 mg, 14%.

Provenance & Evidence