Hydrogen Peroxide → HCID 58046305, compound

Participants

Reaction Steps

To a solution of 5-chloro-4-[4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-2-fluorobenzonitrile (Preparation 19, 290 mg, 0.801 mmol) in DMSO (0.8 mL) was added hydrogen peroxide (545 μL, 16 mmol) followed by potassium carbonate (221 mg, 1.60 mmol). The reaction was stirred at room temperature for 18 hours. The reaction was then purified directly using trilution reverse phase chromatography to furnish the title compound (320 mg, 105%).

Provenance & Evidence