HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-(trifluoromethyl)phenol → Benzoic acid, 4-[4-chloro-3-(trifluoromethyl)phenoxy]-2-(methoxymethyl)-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-(trifluoromethyl)phenol | HCID 80520 | — |
| Reactant | HCID 21075354 | HCID 21075354 | — |
| Product | Benzoic acid, 4-[4-chloro-3-(trifluoromethyl)phenoxy]-2-(methoxymethyl)-, methyl ester | HCID 58046348 | 33% |
Reaction Steps
Prepared according to Preparation 1 using methyl 4-fluoro-2-(methoxymethyl)benzoate (Preparation 35) and 4-chloro-3-(trifluoromethyl)phenol at 120° C. for 48 hours. The title compound was isolated after purification using silica gel column chromatography eluting with 0-10% EtOAc in heptane as a colourless oil (0.140 g, 0.000374, 33% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08685977B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-1ca34a1c544b4f57a5b52d510976c97b |
| Source note | uspto-grants-2014_04 |