Benzenesulfonamide → Benzamide, 2,4,5-trifluoro-N-(phenylsulfonyl)-

Participants

Reaction Steps

To a solution of 2,4,5-trifluorobenzoic acid (0.50 g, 2.8 mmol) in dichloromethane (5 mL) was added N-di-isopropylethylamine (1.8 mL, 1.3 g, 8.5 mmol), WSCDI (0.82 g, 4.2 mmol) and DMAP (0.52 g, 4.2 mmol). After 10 minutes phenylsulfonamide (0.45 g, 4.2 mmol) was added and the reaction left at room temperature for 18 hours. The reaction mixture was concentrated in vacuo and the residue purified by reverse phase chromatography using CH3CN/water as eluent (5:95-95/5 over 30 mins) to yield the title compound (0.60 g, 67%) as a white solid

Provenance & Evidence