2,4,5-Trifluorobenzoic acid → N-(sec-butylsulfonyl)-2,4,5-trifluorobenzamide

HRID 2359312Notes

Reaction equation

HRID 2359312 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:13][CH:14]([S:17]([NH2:20])(=[O:19])=[O:18])[CH2:15][CH3:16]>>[CH:14]([S:17]([NH:20][C:4](=[O:6])[C:3]1[CH:7]=[C:8]([F:12])[C:9]([F:11])=[CH:10][C:2]=1[F:1])(=[O:19])=[O:18])([CH2:15][CH3:16])[CH3:13]

Participants

3

Reactant 2

HCID 5211702,4,5-Trifluorobenzoic acidHCID 20482438Butane-2-sulfonamide

Product 1

HCID 58042392N-(sec-butylsulfonyl)-2,4,5-trifluorobenzamideYield 46%

Procedure

Prepared according to Preparation 42 using 2,4,5-trifluorobenzoic acid (0.25 g, 1.4 mmol) and butane-2-sulfonamide (0.0.29 g, 2.1 mmol) to yield the title compound (0.19 g, 45%) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f862b33ada6f46ce8163a71834b8ef87
Source dataset
uspto-grants-2014_04
Patent number
US08685977B2

Reaction notes

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