Hydrogen Peroxide → 4-[4-Chloro-3-(trifluoromethyl)phenoxy]benzamide

Participants

Reaction Steps

To a solution of 4-[4-chloro-3-(trifluoromethyl)phenoxy]benzonitrile (Preparation 47, 48 g, 161 mmol) in DMSO (500 ml) was added K2CO3 (45 g, 323 mmol) followed by dropwise addition of a 30 wt % aqueous hydrogen peroxide solution (27 ml, 806 mmol) at 15° C. The reaction mixture was stirred for 1 hour at room temperature and the mixture was poured into water (500 ml) to afford a preciptate. The precipitated solid was collected by filtration, azeotroped with toluene, and dried over in vacuo to give 51 g of titled compound.

Provenance & Evidence