Potassium Carbonate → 4-(4-Chloro-3-(trifluoromethyl)phenoxy)benzonitrile

Participants

Reaction Steps

To a solution of 4-chloro-3-(trifluoromethyl)phenol (31.5 g, 160 mmol) in DMSO (200 ml) was added K2CO3 (46.5 g, 337 mmol) at room temperature under nitrogen. After 5 minutes stirring, 4-fluorobenzonitrile (19.4 g, 160 mmol) was added to the mixture in one portion and the resulting mixture was stirred at 100° C. for 18 hours. The reaction mixture was allowed to cool to room temperature and poured into ice-cold 1N aqueous NaOH solution with vigorous stirring. The precipitated solid was collected by filtration and under vacuum to afford 50 g of the title compound.

Provenance & Evidence