1,4-Dioxane hydrochloride → HCID 66990833, compound

Participants

Reaction Steps

8-{4-[2-(Tetrahydro-2H-pyran-4-yloxy)ethoxy]piperidin-1-yl}-1,6-naphthyridine-2-carboxamide (400 mg, 1.00 mmol) produced in Example 6 was dissolved in ethanol (8 mL), to which a 4M hydrochloric acid/dioxane solution (1.0 mL, 4.0 mmol) was then slowly added, followed by stirring at room temperature for 10 minutes. The resulting reaction liquid was concentrated under reduced pressure, and the residue thus obtained was crystallized from ethanol and diethyl ether to give the desired title compound (368 mg, yield 84%).

Provenance & Evidence