HCID 56840225, compound → HCID 58495701, compound

Participants

Reaction Steps

4-(4-Hydroxy-4-phenylpiperidin-1-yl)isoquinoline-6-carboxamide (134 mg, 0.386 mmol) produced in Example 23 was dissolved in trifluoroacetic acid (1 mL)/dichloromethane (1.5 mL), and the resulting mixture was heated to reflux overnight. Upon completion of the reaction, the solvent was distilled off under reduced pressure. The residue thus obtained was purified by silica gel column chromatography (hexane:ethyl acetate, 50:50-0:100, V/V) to give the desired title compound (108 mg, yield 85%).

Provenance & Evidence