HCID 23533634, compound → HCID 66990439, compound

HRID 2359355Notes

Reaction equation

HRID 2359355 reaction equation
CC1C=CC(S([O:11][CH2:12][CH2:13][O:14][CH:15]2[CH2:20][CH2:19][N:18](C(OCC3C=CC=CC=3)=O)[CH2:17][CH2:16]2)(=O)=O)=CC=1.[CH3:31][O:32][CH:33]1[CH2:37][O:36][CH2:35][CH:34]1O>>[CH3:31][O:32][C@H:33]1[CH2:37][O:36][CH2:35][C@H:34]1[O:11][CH2:12][CH2:13][O:14][CH:15]1[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 23533634HCID 23533634, compoundHCID 58495736HCID 58495736, compound

Product 1

HCID 66990439HCID 66990439, compoundYield 85%

Procedure

Using benzyl 4-(2-{[(4-methylphenyl)sulfony]oxy}ethoxy)piperidine-1-carboxylate (2.50 g, 5.77 mmol) produced in Reference Example 1 (1c) and 4-methoxytetrahydrofuran-3-ol (820 mg, 6.94 mmol), the desired title compound (1.20 g, yield 85%) was obtained by the same method as in Reference Examples 1 (1d) and 1 (1e).

Sources & evidence

ORD record
ord-c9de431ebf7f4dc397b2daa025968cc6
Source dataset
uspto-grants-2014_04
Patent number
US08685981B2

Reaction notes

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