Cyclopropylamine → HCID 13157369, compound

Participants

Reaction Steps

A mixture of 3-[p-(2-imidazolyl)phenoxy]-1,2-epoxypropane (4.95 g, 0.023 m) in cyclopropylamine (50 ml) is refluxed at 60° for 30 hours. The mixture is concentrated under reduced pressure and the residue is chromatographed on silica gel, eluting with 5-10% MeOH--CHCl3 saturated with NH3. The free base (IV) (1.21 g, 19%) is crystallized as the dihydrochloride salt from EtOH--MeOH--ether (m.p. 214°-5°).

Provenance & Evidence