Lithium Hydroxide → HCID 58154509, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-methyl 3-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)benzoate (8.5 g, 32 mmol) in THF (80 ml) was added a solution of LiOH (2.3 g, 96 mmol) in water (20 ml). The mixture was stirred for 15 hours at 40° C. The mixture was concentrated and diluted with saturated solution of Na2CO3 (50 ml), washed with ethyl acetate (50 ml×2), The aqueous layer was adjusted to pH=4 by addition of aqueous 3N HCl. The precipitate was collected by filtration and the filtered cake was dried in vacuo to obtain (R)-3-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)benzoic acid as a white solid, (5.8 g, 72% yield).

Provenance & Evidence