2-Aminothiazole → HCID 44552710, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 8-isocyanato-2-(3-(trifluoromethoxy)phenyl)quinoline (0.277 mmol) in toluene (5 mL) was added 2-aminothiazole (0.553 mmol, 55 mg). The mixture was concentrated to dryness, redissolved in pyridine and microwave heated (140° C.×10 min). The reaction mixture was diluted with CH2Cl2, washed with saturate aqueous NaHCO3, water, brine. The organic layer was dried (Na2SO4) and concentrated under reduced pressure. Purification by column chromatography (0% to 100% ethyl acetate in pentane) afforded the desired product. MS (ESI) calcd for C20H13F3N4O2S (m/z): 430.07. found: 431 [M+1].

Provenance & Evidence