Dichloromethane → HCID 66883538, compound

Participants

Reaction Steps

Tert-butyl-4-(3-(8-(thiazole-4-carboxamido)quinolin-2-yl)benzyl)piperazine-1-carboxylate from above was treated with a mixture of 25% TFA in CH2Cl2 for 18 hours, concentrated to dryness. The residue was suspended in CH2Cl2, washed with aqueous NaHCO3 (sat.), dried (Na2SO4) and concentrated. The resulting residue was diluted in a minimal amount of dioxane, treated with a slight excess of HCl in methanol, followed by diethyl ether. The resulting HCl salt of N-(2-(3-(piperazin-1-ylmethyl)phenyl)quinolin-8-yl)thiazole-4-carboxamide was collected by filtration. (24 mg 32% yield over two steps). MS (ESI) calcd for C24H23N5OS (m/z): 429.16. found: 430 [M+1].

Provenance & Evidence