Methanol → Methyl 2-amino-4-fluorobenzoate

Participants

Reaction Steps

To a solution of 2-amino-4-fluorobenzoic acid (2.0 g, 12.9 mmol) in methanol (50 mL) was added thionyl chloride (1.8 mL, 25.8 mmol). The mixture was refluxed overnight and concentrated to dryness. The residue was extracted with CH2Cl2 (30 mL), washed by aq. NaHCO3 (20 mL), water, and brine, dried and concentrated to give methyl 2-amino-4-fluorobenzoate as yellow solid (1.4 g).

Provenance & Evidence