3-Nitrophenol → HCID 58154811, compound

Participants

Reaction Steps

To a mixture of 3-nitrophenol (4.0 g, 28.8 mmol), tert-butyl 3-hydroxypyrrolidine-1-carboxylate (5.94 g, 31.7 mmol), PPh3 (8.3 g, 31.7 mmol) in THF (40 mL) at 0° C. over argon was added DEAD (5.52 g, 31.7 mmol). The reaction was warmed to room temperature and stirred for 18 hours. The reaction mixture was concentrated and purified by column chromatography to obtain tert-butyl 3-(3-nitrophenoxy)pyrrolidine-1-carboxylate (8.73 g, 98% yield)

Provenance & Evidence