3-Nitrophenol → (R)-2,2-dimethyl-4-((3-nitrophenoxy)methyl)-1,3-dioxolane

HRID 2359411노트

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HRID 2359411 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].Cl[CH2:18][C@H:19]1[CH2:23][O:22][C:21]([CH3:25])([CH3:24])[O:20]1>CN(C=O)C>[CH3:24][C:21]1([CH3:25])[O:20][C@H:19]([CH2:18][O:10][C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[CH2:23][O:22]1

참가 물질

5

반응물 3

HCID 111373-NitrophenolHCID 11430Potassium CarbonateHCID 2734443(R)-(+)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane

생성물 1

HCID 58552880(R)-2,2-dimethyl-4-((3-nitrophenoxy)methyl)-1,3-dioxolane수율 52%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
160 °C

실험 절차

3-Nitrophenol (2.0 g, 14.37 mmol) was taken up in 20 mL of anhydrous DMF along with anhydrous potassium carbonate (4.96 g, 35.93 mmol) and (R)-4-(chloromethyl)-2,2-dimethyl-1,3-dioxolane (2.55 mL, 18.68 mmol). The resulting reaction mixture was heated in the microwave reactor, with stirring, at 160° C. for 4 h. The crude reaction mixture was rinsed with water, filtered and extracted with dichloromethane (3×15 mL). The combined organic layers were dried (Na2SO4) and concentrated under reduced pressure. The resulting residue was purified by chromatography using ethyl acetate: pentane to obtain the desired product as an amber-colored oil (52%).

후처리

  1. customThe resulting reaction mixture
  2. temperaturewas heated in the microwave reactor
  3. customThe crude reaction mixture
  4. washwas rinsed with water
  5. filtrationfiltered
  6. extractionextracted with dichloromethane (3×15 mL)
  7. dry with materialThe combined organic layers were dried (Na2SO4)
  8. concentrationconcentrated under reduced pressure
  9. customThe resulting residue was purified by chromatography

출처 및 근거

ORD 기록
ord-a6b43f4bb01547fc9afadc59964bb7fd
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08685970B2

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