Thionyl Chloride → HCID 58154748, compound

Participants

Reaction Steps

To a solution of (2-(3-(trifluoromethyl)phenyl)quinolin-8-yl)methanol (0.67 g, 2.2 mmol) in CH2Cl2 (20 ml) was added SOCl2 (0.32 ml, 4.4 mmol) dropwise at 0° C. The mixture was stirred at room temperature for 2 h, and then concentrated. The residue was purified by column chromatography (1:15 ethylacetate in pentane) to give the product as a white solid (0.668 g, 94% yield).

Provenance & Evidence