反应详情

To a solution of 1-(3-(trifluoromethoxy)phenyl)ethanone (5.0 g, 24.6 mmol) dissolved in 1,4-dioxane (75 mL) and water (4 mL) was added SeO2 (4.38 g, 39.4 mmol) in one portion. The mixture was refluxed overnight. The mixture was filtered to remove the black precipitate. The filtrate was concentrated and purified by column chromatography (1:5 Ethyl Acetate/Pentane) to give 2-oxo-2-(3-(trifluoromethoxy)phenyl)acetaldehyde as a yellow oil (5.3 g, 98% yield).

1. temperatureThe mixture was refluxed overnight
2. filtrationThe mixture was filtered
3. customto remove the black precipitate
4. concentrationThe filtrate was concentrated
5. custompurified by column chromatography (1:5 Ethyl Acetate/Pentane)