o-Xylyl bromide → HCID 59336189, compound

HRID 2359481Notes

Reaction equation

HRID 2359481 reaction equation
[CH3:1][C:2]1[C:7]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[C:6]([CH3:16])[N:5]=[C:4]([O:17][CH2:18][C:19]([N:21]([CH3:28])[CH:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[O:20])[N:3]=1.[CH3:29][C:30]1[CH:37]=[CH:36][CH:35]=[CH:34][C:31]=1[CH2:32]Br>>[CH3:16][C:6]1[C:7]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:12])[CH3:13])=[C:2]([CH3:1])[N:3]=[C:4]([O:17][CH2:18][C:19]([N:21]([CH3:28])[CH:22]2[CH2:23][CH2:24][N:25]([CH2:29][C:30]3[CH:37]=[CH:36][CH:35]=[CH:34][C:31]=3[CH3:32])[CH2:26][CH2:27]2)=[O:20])[N:5]=1

Participants

3

Reactant 2

HCID 6992o-Xylyl bromideHCID 59336171Tert-butyl 4,6-dimethyl-2-(2-(methyl(piperidine-4-yl)amino)-2-oxoethoxy)pyrimidine-5-ylcarbamate

Product 1

HCID 59336189HCID 59336189, compound

Procedure

The title compound was synthesized from Compound 31 and 2-methylbenzyl bromide in the same manner as in Example 32.

Sources & evidence

ORD record
ord-ccf55523b3cc426083beb9a4731d585a
Source dataset
uspto-grants-2014_04
Patent number
US08685989B2

Reaction notes

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