Furan, 2-(bromomethyl)tetrahydro- → Tert-butyl 4,6-dimethyl-2-(2-(methyl(1-((tetrahydrofuran-2-yl)methyl)piperidine-4-yl)amino)-2-oxoethoxy)pyrimidine-5-ylcarbamate

HRID 2359486Notes

Reaction equation

HRID 2359486 reaction equation
[CH3:1][C:2]1[C:7]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[C:6]([CH3:16])[N:5]=[C:4]([O:17][CH2:18][C:19]([N:21]([CH3:28])[CH:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[O:20])[N:3]=1.[CH2:29](Br)[CH:30]1[O:34][CH2:33][CH2:32][CH2:31]1>>[CH3:16][C:6]1[C:7]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:12])[CH3:13])=[C:2]([CH3:1])[N:3]=[C:4]([O:17][CH2:18][C:19]([N:21]([CH3:28])[CH:22]2[CH2:23][CH2:24][N:25]([CH2:29][CH:30]3[CH2:31][CH2:32][CH2:33][O:34]3)[CH2:26][CH2:27]2)=[O:20])[N:5]=1

Participants

3

Reactant 2

HCID 14501Furan, 2-(bromomethyl)tetrahydro-HCID 59336171Tert-butyl 4,6-dimethyl-2-(2-(methyl(piperidine-4-yl)amino)-2-oxoethoxy)pyrimidine-5-ylcarbamate

Product 1

HCID 59336091Tert-butyl 4,6-dimethyl-2-(2-(methyl(1-((tetrahydrofuran-2-yl)methyl)piperidine-4-yl)amino)-2-oxoethoxy)pyrimidine-5-ylcarbamate

Procedure

The title compound was synthesized from Compound 31 and tetrahydrofurfuryl bromide in the same manner as in Example 32.

Sources & evidence

ORD record
ord-d4a9144dbaac4b03bea5f1018644efd8
Source dataset
uspto-grants-2014_04
Patent number
US08685989B2

Reaction notes

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