1-Benzyl-4-piperidylamine → HCID 59336085, compound

HRID 2359494Notes

Reaction equation

HRID 2359494 reaction equation
C(OC(NC1C(C)=NC(OCC(O)=O)=NC=1C)=O)(C)(C)C.NC1CCN(CC2C=CC=CC=2)CC1.[CH2:36]([N:43]1[CH2:48][CH2:47][CH:46]([NH:49][C:50](=[O:69])[CH2:51][O:52][C:53]2[N:58]=[C:57]([CH3:59])[C:56]([NH:60][C:61](=[O:67])[O:62][C:63]([CH3:66])([CH3:65])[CH3:64])=[C:55]([CH3:68])[N:54]=2)[CH2:45][CH2:44]1)[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>>[CH2:36]([N:43]1[CH2:44][CH2:45][CH:46]([NH:49][C:50](=[O:69])[CH2:51][O:52][C:53]2[N:54]=[C:55]([CH3:68])[C:56]([NH:60][C:61](=[O:67])[O:62][C:63]([CH3:65])([CH3:66])[CH3:64])=[C:57]([CH3:59])[N:58]=2)[CH2:47][CH2:48]1)[C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1.[CH3:59][C:57]1[C:56]([NH:60][C:61](=[O:67])[O:62][C:63]([CH3:66])([CH3:64])[CH3:65])=[C:55]([CH3:68])[N:54]=[C:53]([O:52][CH2:51][C:50](=[O:69])[NH:49][CH:46]2[CH2:47][CH2:48][NH:43][CH2:44][CH2:45]2)[N:58]=1

Participants

5

Reactant 3

HCID 4158521-Benzyl-4-piperidylamineHCID 593361682-(5-(Tert-butoxycarbonylamino)-4,6-dimethylpyrimidine-2-yloxy)acetic acidHCID 68412568HCID 68412568, compound

Product 2

HCID 59336085HCID 59336085, compoundHCID 68412568HCID 68412568, compound

Procedure

Tert-butyl 2-(2-(1-benzylpiperidine-4-ylamino)-2-oxoethoxy)-4,6-dimethyl-pyrimidine-5-ylcarbamate was synthesized from Compound 9 and 4-amino-1-benzylpiperidine in the same manner as in Example 49. The title compound was then synthesized from tert-butyl 2-(2-(1-benzylpiperidine-4-ylamino)-2-oxoethoxy)-4,6-dimethyl-pyrimidine-5-ylcarbamate in the same manner as in Example 31.

Sources & evidence

ORD record
ord-57e7b270a0fc4756bca946f22a5cc18c
Source dataset
uspto-grants-2014_04
Patent number
US08685989B2

Reaction notes

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