1-benzyl-N-methylpiperidin-4-amine → N-(1-benzylpiperidine-4-yl)-2-(4,6-dimethyl-5-nitropyrimidine-2-ylamino)-N-methylacetamide

HRID 2359499Notes

Reaction equation

HRID 2359499 reaction equation
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([CH3:11])[N:5]=[C:4]([NH:12][CH2:13][C:14]([OH:16])=O)[N:3]=1.[CH2:17]([N:24]1[CH2:29][CH2:28][CH:27]([NH:30][CH3:31])[CH2:26][CH2:25]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([N:24]1[CH2:29][CH2:28][CH:27]([N:30]([CH3:31])[C:14](=[O:16])[CH2:13][NH:12][C:4]2[N:5]=[C:6]([CH3:11])[C:7]([N+:8]([O-:10])=[O:9])=[C:2]([CH3:1])[N:3]=2)[CH2:26][CH2:25]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 41361281-benzyl-N-methylpiperidin-4-amineHCID 593361022-(4,6-Dimethyl-5-nitropyrimidine-2-ylamino)acetic acid

Product 1

HCID 59336190N-(1-benzylpiperidine-4-yl)-2-(4,6-dimethyl-5-nitropyrimidine-2-ylamino)-N-methylacetamide

Procedure

The title compound was synthesized from Compound 11 and 1-benzyl-N-methylpiperidine-4-amine in the same manner as in Example 49.

Sources & evidence

ORD record
ord-205cf48c16634e1d9fc219b1f4c1dcfd
Source dataset
uspto-grants-2014_04
Patent number
US08685989B2

Reaction notes

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