HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 2-(3-hydroxyphenylaminocarbonyl)-L-proline hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | N-Cbz-[2-(3-hydroxyphenylaminocarbonyl)]-L-proline | HCID 20757882 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-(3-hydroxyphenylaminocarbonyl)-L-proline hydrobromide | HCID 69768390 | 70% |
Reaction Steps
To N-Cbz-[2-(3-hydroxyphenylaminocarbonyl)]-L-proline (5.0 mmol) in HOAc (10 mL) was added 30% HBr in acetic acid and the solution stirred for 40 min. The reaction was quenched by addition of 100 mL ethylether, and the resulting precipitate collected and recrystalized from MeOH/Et2O to afford 3.5 mmol 2-(3-hydroxyphenylaminocarbonyl)-L-proline hydrobromide (70%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06852752B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-9bb638b89e484910aa33f3ac3768b197 |
| Source note | uspto-grants-2005_02 |