Maleic Acid → HCID 59336188, compound

HRID 2359514Notes

Reaction equation

HRID 2359514 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:36])[C:15](=[O:35])[CH2:16][NH:17][C:18]2[C:23]([CH3:24])=[CH:22][N:21]=[C:20]([NH:25]CC3C=CC(OC)=CC=3)[N:19]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:37][C:38]1[N:43]=[C:42]([NH:44][CH2:45][C:46]([N:48]([CH:50]2[CH2:55][CH2:54][N:53]([CH2:56][C:57]3[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=3)[CH2:52][CH2:51]2)[CH3:49])=[O:47])[C:41]([CH3:63])=[CH:40][N:39]=1.[C:64]([OH:71])(=[O:70])/[CH:65]=[CH:66]\[C:67]([OH:69])=[O:68]>CO>[NH2:25][C:20]1[N:19]=[C:18]([NH:17][CH2:16][C:15]([N:14]([CH:11]2[CH2:12][CH2:13][N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:9][CH2:10]2)[CH3:36])=[O:35])[C:23]([CH3:24])=[CH:22][N:21]=1.[C:64]([OH:71])(=[O:70])/[CH:65]=[CH:66]\[C:67]([OH:69])=[O:68].[NH2:37][C:38]1[N:43]=[C:42]([NH:44][CH2:45][C:46]([N:48]([CH:50]2[CH2:55][CH2:54][N:53]([CH2:56][C:57]3[CH:58]=[CH:59][CH:60]=[CH:61][CH:62]=3)[CH2:52][CH2:51]2)[CH3:49])=[O:47])[C:41]([CH3:63])=[CH:40][N:39]=1

Participants

6

Reactant 3

HCID 444266Maleic AcidHCID 59336094HCID 59336094, compoundHCID 59336188HCID 59336188, compound

Product 2

HCID 59336188HCID 59336188, compoundHCID 68416174HCID 68416174, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(2-Amino-5-methylpyrimidine-4-ylamino)-N-(1-benzylpiperidine-4-yl)-N-methylacetamide was synthesized from Compound 110 in the same manner as in Example 108. Then, to a methanol solution of 2-(2-amino-5-methylpyrimidine-4-ylamino)-N-(1-benzylpiperidine-4-yl)-N-methylacetamide, 1 equivalent of maleic acid was added and the mixture was concentrated under reduced pressure to give the title compound.

Workup

  1. concentrationthe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-2c6e52bc409447e693678ae2eb62d8f2
Source dataset
uspto-grants-2014_04
Patent number
US08685989B2

Reaction notes

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