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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2359525Generated: October 31, 2026

1-Cyclopropanecarbonyl-N-methylpiperidin-4-amine → 2-(6-chloropyridazine-3-yloxy)-N-(1-(cyclopropanecarbonyl)piperidine-4-yl)-N-methylacetamide

https://huagongshe.com/reaction/2359525

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Cyclopropanecarbonyl-N-methylpiperidin-4-amineHCID 60817866—
ReactantEthyl 2-(6-chloropyridazine-3-yloxy)acetateHCID 86641965—
Product2-(6-chloropyridazine-3-yloxy)-N-(1-(cyclopropanecarbonyl)piperidine-4-yl)-N-methylacetamideHCID 8664196463%

Reaction Steps

The title compound was synthesized from ethyl 2-(6-chloropyridazine-3-yloxy)acetate and cyclopropyl (4-(methylamino)piperidine-1-yl)methanone in the same manner as in Example 105 (63% yield, in 2 steps).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08685989B2
Source datasetuspto-grants-2014_04
ORD IDord-0045763f260944eba8243a1439d9f6f1
Source noteuspto-grants-2014_04