HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HCID 58315415, Verbindung → HCID 178455434, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | HCID 58315415 | HCID 58315415 | — |
| Edukt | HCID 178455437 | HCID 178455437 | — |
| Produkt | HCID 178455434 | HCID 178455434 | 66% |
Reaktionsschritte
Following Buchwald Procedure A, 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonitrile (95 mg, 0.385 mmol) and 5-(tert-butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamine (101 mg, 0.424 mmol) (Example C) gave 114 mg of 2-[5-(tert-butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamino]-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonitrile [following SiO2 chromatography eluting with 1-2% MeOH/dichloromethane and subsequent trituration with diethyl ether].
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08685980B2 |
| Quelldatensatz | uspto-grants-2014_04 |
| ORD ID | ord-cae3da0728044b17910d0c4f78f9eab6 |
| Quellennotiz | uspto-grants-2014_04 |