HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Acetylpiperazine → HCID 58315399, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Acetylpiperazine | HCID 83795 | — |
| Reactant | 7-cyclopentyl-2-(5-formyl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide | HCID 58315440 | — |
| Product | HCID 58315399 | HCID 58315399 | — |
Reaction Steps
Following General Procedure B, 7-cyclopentyl-2-(5-formyl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (200 mg, 0.528 mmol) and 1-acetyl piperazine (75 mg, 0.581 mmol) gave 2-[5-(4-acetyl-piperazin-1-ylmethyl)-pyridin-2-ylamino]-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide as an off white solid (96 mg, 37%) [following SiO2 chromatography, eluting with 0-10% (2M NH3 in MeOH)/dichloromethane]. MS (ESI) m/z 491.2 (M+H)+ (method A).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08685980B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-1cf9c70cd0854a07aaa7e863c530a7bc |
| Source note | uspto-grants-2014_04 |