Cesium carbonate → HCID 67191479, compound

Participants

Reaction Steps

A mixture of Compound 14d (1.0 g; 3.79 mmol), 3-cyanophenol (0.587 g; 4.93 mmol) and Cs2CO3 (4.93 g; 15.13 mmol) in CH3CN (25 mL) was stirred at room temperature for 2 h. The suspension was poured into ice-water and extracted with CH2Cl2 (3×50 mL). The combined organic phases were dried over MgSO4 and concentrated to afford Compound 14e. 1H NMR (300 MHz, CDCl3): δ 9.40 (s, 1H), 9.25 (s, 1H), 8.70 (d, 1H), 8.45 (m, 1H), 7.45-7.65 (m, 4H), 7.35 (m, 1H), 4.50 (q, 2H), 1.45 (t, 3H); MS: m/z 347.2 (M+H)+.

Provenance & Evidence