Bromine → HCID 178488960, compound

Participants

Reaction Steps

To a suspension of 55 (2.56 g, 0.0092 mol) in CHCl3 (75 ml) was added dropwise with stirring a solution of bromine (1.55 g, 0.0096 mol) in CHCl3 (75 ml). After stirring for 3 days, saturated NaHCO3 was added, the layers separated and the aqueous layer extracted with CHCl3 (2×). The organic extracts were dried, filtered and concentrated to dryness. The residue was chromatographed on silica gel and the product eluted with 1.5% CH3OH--CHCl3 to yield 2.25 g (69%) of 56, m.p. 228.30° C. (CHCl3).

Provenance & Evidence