(Diethylamino)sulfur trifluoride → HCID 58247415, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (diethylamino)sulfur trifluoride (0.036 mL; 0.28 mmol) in CH2Cl2 (2 mL), cooled to −78° C., was added a solution of Compound 18b (100 mg; 0.21 mmol) in CH2Cl2 (1 mL). The reaction mixture was stirred at −78° C. for 20 min. The resultant mixture was partitioned between EtOAc and H2O. The organic phase was washed with water and dried over Na2SO4. The mixture was filtered and the solvent removed under reduced pressure to give the crude material. The crude material was purified by flash column chromatography (SiO2), eluting with a heptane-EtOAc gradient to afford Compound 18c (50 mg; 50% yield). MS: m/z 480.2 (M+H)+.

Provenance & Evidence