Hydrochloric Acid → HCID 86662768, compound

Participants

Reaction Conditions

Reaction Steps

2.0 g (4 mmol) of methyl 4-{(2,2-difluoroethyl)[(2-iodobenzyl)sulfonyl]amino}-1,3-thiazole-5-carboxylate were dissolved in 25 ml of dimethylformamide and cooled to 0° C., and 143.3 mg (6 mmol) of sodium hydride were added. After addition, the mixture was warmed to RT and stirred for 12 h. Thereafter, the reaction mixture was poured onto 100 ml of water and brought to pH 4-5 with 2N HCl. The precipitate formed was filtered off and washed with water. This gave 1.7 g of compound I-a-14.

Provenance & Evidence