N-[4-(thiazol-2-yl)benzyl]pyridin-2-ylsulfonamide → N-[4-(thiazol-2-yl)benzyl]pyridin-3-ylsulfonamide

Participants

Reaction Steps

Reaction and post-treatment were carried out in the same manner as in Example 2-(a) except for using tert-butyl[tert-butoxycarbonyl(6-hydroxymethylpyridin-2-yl)amino]acetate (279 mg, 0.824 mmol) obtained in Reference Example 3-(b), and using N-[4-(thiazol-2-yl)benzyl]pyridin-2-ylsulfonamide (275 mg, 0.830 mmol) obtained in Reference Example 5 in place of N-[4-(thiazol-2-yl)benzyl]pyridin-3-ylsulfonamide to afford the title compound (496 mg) as a white foam. (Yield: 92%) Mass spectrum (FAB, m/z): 652 (M++1).

Provenance & Evidence