4-fluoro-N-[4-(thiazol-2-yl)benzyl]benzenesulfonamide → N-[4-(thiazol-2-yl)benzyl]pyridin-3-ylsulfonamide

Participants

Reaction Steps

Reaction and post-treatment were carried out in the same manner as in Example 2-(a) except for using tert-butyl([tert-butoxycarbonyl(6-hydroxymethylpyridin-2-yl)amino]acetate (101 mg, 0.298 mmol) obtained in Reference Example 3-(b), and using 4-fluoro-N-[4-(thiazol-2-yl)benzyl]benzenesulfonamide (105 mg, 0.301 mmol) obtained in Reference Example 6 in place of N-[4-(thiazol-2-yl)benzyl]pyridin-3-ylsulfonamide to afford the title compound (181 mg) as a white foam. (Yield: 91%) Mass spectrum (FAB, m/z): 669 (M++1).

Provenance & Evidence