反应详情

Reaction was carried out in the same manner as in Example 27 except for using (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetic acid hydrochloride (21.6 mg, 0.0367 mmol) obtained in Example 7-(b) in place of tert-butyl[tert-butoxycarbonyl(6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-yl)amino]acetate. After completion of the reaction, the reaction solution was concentrated under reduced pressure, and a saturated aqueous sodium hydrogencarbonate solution was added to the residue, followed by extraction with ethyl acetate. The separated organic layer was dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to afford the title compound (17.6 mg) as a colorless oil. (Yield: 95%)

1. customReaction
2. customAfter completion of the reaction
3. concentrationthe reaction solution was concentrated under reduced pressure
4. additiona saturated aqueous sodium hydrogencarbonate solution was added to the residue
5. extractionfollowed by extraction with ethyl acetate
6. dry with materialThe separated organic layer was dried over anhydrous magnesium sulfate
7. concentrationconcentrated under reduced pressure