1,4-Dioxane hydrochloride → (6-Phenylpyridazin-3-ylmethyl)amine hydrochloride

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-[bis(tert-butoxycarbonyl)aminomethyl]-6-phenylpyridazine (178 mg, 0.462 mmol) obtained in Reference Example 2-(b) in methylene chloride (2.33 ml) was added a 4N hydrogen chloride/1,4-dioxane solution (2.33 ml, 9.32 mmol), followed by stirring at 30° C. for 1 hour. After completion of the reaction, the reaction solution was concentrated under reduced pressure to afford the title compound (122 mg) substantially quantitatively as a slightly brown solid.

Provenance & Evidence