HCID 21850027, compound → HCID 16045945, compound

HRID 2359852Notes

Reaction equation

HRID 2359852 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[CH:9]=O.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[C:14]=1[CH2:21][CH2:22][C:23]#[N:24].CC([O-])(C)C.[K+]>>[CH3:20][O:19][C:15]1[CH:16]=[CH:17][CH:18]=[C:13]([O:12][CH3:11])[C:14]=1[CH2:21][C:22]1[C:23]([NH2:24])=[N:2][C:3]2[C:4]([CH:9]=1)=[CH:5][N:6]=[CH:7][CH:8]=2

Participants

4

Reactant 3

HCID 21850027HCID 21850027, compoundHCID 23665647Potassium tert-butoxideHCID 450739641159822-25-9

Product 1

HCID 16045945HCID 16045945, compound

Procedure

The title compound was synthesized according to EXAMPLE 11 from 4-amino-3-pyridine carboxaldehyde hydrochloride and 3-(2,6-dimethoxyphenyl)propionitrile. One equivalent of potassium tert-butylate was additionally used.

Sources & evidence

ORD record
ord-c85610ba365f4524b98e281552f05953
Source dataset
uspto-grants-2014_04
Patent number
US08686002B2

Reaction notes

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