Acetic Acid → HCID 68553228, compound

Participants

Reaction Steps

A mixture of 2.78 g (10.21 mmol) (2-aminobenzyl)(2,6-dimethoxybenzyl)amine and 1.5 g BrCN in 60 mL ethanol was heated at reflux for 10 hours. After evaporation, the resulting residue was dissolved in a small amount of dioxane, mixed with one equivalent 4N HCl in dioxane, the resulting solids were filtered out and dried. The resulting crude product was purified by MPLC (silica gel: Bischoff Prontoprep 60-2540-C18E, 32 μm; mobile phase: CH3CN/H2O+0.1% acetic acid), the resulting product was then dissolved in acetone and converted to the corresponding acetate by adding one equivalent of glacial acetic acid. Stirring the resulting solids [in] n-pentane and drying yielded 580 mg white solids.

Provenance & Evidence