참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzene, 1-chloro-3-isocyanato- | HCID 17968 | — |
| 반응물 | 3-(2-Chloroethyl)-1,3-oxazolidin-2-one | HCID 75633 | — |
| 촉매 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(3-chlorophenyl)-N'-(2-chloroethyl)imidazolidinone | HCID 13824503 | 78.7% |
반응 단계
A mixture of 3-chlorophenyl isocyanate (7.65 g, 50 mmoles), N-(2-chloroethyl)-2-oxazolidinone (7.5 g, 50 mmoles) and anhydrous AlCl3 (40 mg, 0.3 mmole) is heated at 195° C. for 6 hours with stirring. The reaction mixture is dissolved in dichloromethane and the resulting solution is washed with water twice. The dichloromethane solution is dried and evaporated and the residue distilled at reduced pressure. The distillate is recrystallized from hot hexane to give 10.2 g (78.4 percent) of the desired product, m.p. 64° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04642351 |
|---|
| 출처 데이터셋 | uspto-grants-1987_02 |
|---|
| ORD ID | ord-94979adb2c224e2eab50346924169805 |
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| 출처 메모 | uspto-grants-1987_02 |
|---|
